The Children's Hospital University of Illinois
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Northwestern University - Ann and Robert H. Lurie Children's Hospital of Chicago
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Medical College of Wisconsin - Children's Hospital of Wisconsin
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Rush University Children's Hospital
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University of Chicago - Comer Children's Hospital
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University of Iowa - Stead Family Children's Hospital
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University of Minnesota - Masonic Children's Hospital
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University of Wisconsin - American Family Children's Hospital
Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells
The present trial will consist of the treatment of 20 pediatric and adult Hematopoietic Stem Cell Transplantation (HSCT) recipients or immunocompromised participants diagnosed with opportunistic Cytomegalovirus (CMV) infections with virus-specific, antigen-selected T-cells. CMV-specific T-cells will be isolated from donor leukapheresis products using the CliniMACS® Prodigy. Prior studies on transfer of CMV specific T-cells have been shown to be safe and efficacious in the treatment of CMV infections. The main trial objective is to evaluate the feasibility and safety of CMV-specific T-cell transfer in adult and pediatric participants suffering from CMV infections or reactivation following HSCT or due to other immunocompromised states (e.g.; primary immunodeficiency, cytotoxic therapy). Participants will be followed for one year.
October 15, 2020- More Infections – University of Wisconsin - American Family Children's Hospital posts